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GLP-1s & Nail Detachment? New Study Reveals a Surprising Side Effect

Oct 7, 2026 · 35K views

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Review
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Nails

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DescriptionCould your nails be affected by GLP-1 medications such as Ozempic, Wegovy, Mounjaro, or Zepbound? Dermatologist Dr. Dray examines a new study investigating a potential link between GLP-1 receptor agonists and nail problems, including onycholysis, or separation of the nail from the nail bed. The study found that nail deMore
Could your nails be affected by GLP-1 medications such as Ozempic, Wegovy, Mounjaro, or Zepbound? Dermatologist Dr. Dray examines a new study investigating a potential link between GLP-1 receptor agonists and nail problems, including onycholysis, or separation of the nail from the nail bed. The study found that nail detachment and nail discoloration were reported more frequently among GLP-1 users than among people with obesity and/or type 2 diabetes who had never used GLP-1 medications. However, the findings do not prove that GLP-1 medications cause nail detachment. Dr. Dray explains the important limitations of the study, including the fact that nearly half of GLP-1 users reported nail problems before starting treatment and that the association disappeared when researchers looked specifically at new-onset nail abnormalities. The video also discusses GLP-1 medications, weight loss, nutritional deficiencies, and nail health, including research on vitamin D, iron, B vitamins, calcium, and overall dietary intake during GLP-1 treatment. Dr. Dray explains what onycholysis looks like, other common causes of nail separation, what to do if you notice your nails lifting from the nail bed, and whether you should stop a GLP-1 medication because of nail changes. Related videos from Dr. Dray: Skin Benefits of GLP-1 Medications https://youtu.be/vESsyr2i6iA Can Skincare Fix Ozempic Face? https://youtu.be/zURv_nMTUc0 Nutritional Deficiencies From GLP-1 Medications https://youtu.be/SXjwBXI

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