Can Ozempic & Wegovy Improve Your Skin? Skin Benefits of GLP-1s

Can GLP-1 medications like semaglutide and tirzepatide actually improve inflammatory skin diseases? Dermatologist Dr. Dray explores the emerging research connecting GLP-1 medications, weight loss, metabolic health, and inflammation, including what this could mean for psoriasis, psoriatic arthritis, and hidradenitis suppurativa (HS). GLP-1 medications are best known for treating type 2 diabetes and obesity, but researchers are increasingly investigating their potential effects on inflammation. This video explains why adipose tissue can contribute to systemic inflammation, how GLP-1 signaling may influence inflammatory pathways, and whether improvements in skin disease can occur beyond the effects of weight loss. Dr. Dray discusses the latest evidence, including the TOGETHER-PsO trial, which investigated tirzepatide in people with moderate-to-severe psoriasis and overweight or obesity, as well as emerging research on GLP-1 medications and hidradenitis suppurativa. The video also covers: • What GLP-1 medications are and how they work • Semaglutide vs. tirzepatide • Why obesity and inflammation are connected • GLP-1 medications and psoriasis • Tirzepatide and psoriasis clearance • GLP-1 medications and psoriatic arthritis • GLP-1 medications and hidradenitis suppurativa • Whether GLP-1s have anti-inflammatory effects beyond weight loss • Why metabolic health matters in inflammatory skin disease • Whether everyone with psoriasis or HS should take a GLP-1 • Common GLP-1 side ef